RT Article
T1 So rare we need to hunt for them: reframing the ethical debate on incidental findings
JF Genome medicine
VO 7
SP 1
OP 7
A1 Schuol, Sebastian 1977-
A1 Schickhardt, Christoph 1978-
A1 Wiemann, Stefan
A1 Bartram, Claus R. 1952-
A1 Tanner, Klaus 1953-
A1 Eils, Roland 1965-
A1 Meder, Benjamin
A1 Richter, Daniela
A1 Glimm, Hanno 1967-
A1 Kalle, Christof von 1962-
A1 Winkler, Eva C. 1971-
LA English
PB BioMed Central
YR 2015
UL https://www.ixtheo.de/Record/175582940X
AB Incidental findings are the subject of intense ethical debate in medical genomic research. Every human genome contains a number of potentially disease-causing alterations that may be detected during comprehensive genetic analyses to investigate a specific condition. Yet available evidence shows that the frequency of incidental findings in research is much lower than expected. In this Opinion, we argue that the reason for the low level of incidental findings is that the filtering techniques and methods that are applied during the routine handling of genomic data remove these alterations. As incidental findings are systematically filtered out, it is now time to evaluate whether the ethical debate is focused on the right issues. We conclude that the key question is whether to deliberately target and search for disease-causing variations outside the indication that has originally led to the genetic analysis, for instance by using positive lists and algorithms.
NO Gesehen am 23.04.2021
K1 Gene Panel
K1 Genomic Research
K1 Health Relevance
K1 Incidental Finding
K1 Research Participant
DO 10.1186/s13073-015-0198-3